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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: Although rare tumors account for a non-negligible number, the practice of precision medicine and developmentHerein, by reviewing the epidemiological data of Chinese solid tumors and publications defining raretumors in other areas, we proposed a definition of rare tumor in China, including 515 tumor types withLastly, we pinpointed the current recommendation chance for patients with rare tumors to be involvedand guarantee a bright future for rare tumor patients.

Keywords： rare tumors     diagnosis flowchart     treatment strategy     clinical trials recommendation    

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Distinct community assembly processes underlie significant spatiotemporal dynamics of abundant and rare

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 6, doi: 10.1007/s11783-021-1513-4

Abstract:

• Season and landform influenced spatiotemporal patterns of abundant and rare

Keywords： Rare taxa     Biogeography     Community assembly     Bacterioplankton     The Yangtze River    

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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 649-674 doi: 10.1007/s11684-023-1018-6

Abstract: residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients with tumorsand strategies for the detection of cancer, and emphasizes the application of MRD detection in solid tumors

Keywords： MRD     solid tumor     CTC     ctDNA    

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Recovery of rare and precious metals from urban mines—A review

Mengmeng Wang, Quanyin Tan, Joseph F. Chiang, Jinhui Li

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 5, doi: 10.1007/s11783-017-0963-1

Abstract: The recovery of rare and precious metals (RPMs) from urban mines has attracted increasing attention from

Keywords： Rare and precious metals (RPMs)     Distribution characteristics     Recycling technology     Emerging technology    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large subset of refractory patients presents poor responsiveness to ICB therapy; and the underlying mechanism remains elusive. Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy. Nevertheless, a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance. Here, we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic strategies    

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Characteristics and Exploitation of Rare Earth,Rare Metal and Rare-Scattered Element Minerals in China

Wang Denghong, Sun Yan, Dai Hongzhang, Guo Weiming, Zhao Zhi, Zhao Ting,Li Jiankang, Wang Chenghui, Huang Fan, Yu Yang, Li Dexian

Strategic Study of CAE 2019, Volume 21, Issue 1,   Pages 119-127 doi: 10.15302/J-SSCAE-2019.01.017

Abstract:

China is rich in rear earth, rear metal, and rare-scattered element (suggestions for their development and utilization, and further emphasize the basic idea that “rareearth should be regulated, rare metal should be found when needed, and rare-scattered elements should

Keywords： rare earth     rear metal     and rare-scattered element minerals     resource characteristics     exploitation    

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Migration of ammonium nitrogen in ion-absorbed rare earth soils during and post mining: a column study

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1702-4

Abstract:

● Column experiments with an inclined slope were applied to simulate NH4–N transport.

Keywords： Ion-absorbed rare earth     Ammonium nitrogen transport     HYDRUS-2D     Numerical simulation    

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Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract: outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumorsNon-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy.

Keywords： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 256-264 doi: 10.1007/s11684-009-0052-3

Abstract: More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by using small molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currentlytargeted at molecular markers which may play important roles in gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an importantoption.

Keywords： target therapy     gynecologic malignant tumors     clinical trail     molecular medicine    

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High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumorsWe tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumorsrepetitive matrix protein 4 (SRRM4) was overexpressed in FAK6/7-positive pancreatic tumorsand breast tumors, which promoted the formation of FAK6/7 in cells.

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 284-286 doi: 10.1007/s11684-017-0514-y

Abstract: In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who

Keywords： arsenic trioxide     APL     rhabdomyolysis    

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Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1584-1594 doi: 10.1007/s11705-022-2189-4

Abstract: The separation of rare earth elements is particularly difficult due to their similar physicochemicalThe differences of the ionic magnetic moment among rare earths are greater than that of ionic radius.Herein, a novel method based on the large ionic magnetic moment differences of rare earth elements wasRare earths were firstly dissolved in the ionic liquid, then the ordering degree of them was improvedthe Z-bond effect, and finally the magnetic moment differences between paramagnetic and diamagnetic rare

Keywords： rare earth element     different magnetic moment     magnetic separation     ionic liquid    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable.
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Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 317-321 doi: 10.1007/s11684-012-0203-9

Abstract: order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromal tumorsmedian follow-up of 844 days (52–2 145), we found that as National Institutes of Health suggested, tumorspatients with tumor size≤10 cm and>10 cm were 62.3% and 41.8%, respectively (P = 0.002), Tumorswith mitotic index≤5/50 HPF had a higher 3-year survival rate than tumors with mitotic index>5From the present study, we can conclude that besides tumors size and mitotic index, tumor location and

Keywords： gastrointestinal stromal tumors     surgery     survival    

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Title Author Date Type Operation

Rare tumors: a blue ocean of investigation

Journal Article

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Distinct community assembly processes underlie significant spatiotemporal dynamics of abundant and rare

Journal Article

Minimal residual disease in solid tumors: an overview

Journal Article

Recovery of rare and precious metals from urban mines—A review

Mengmeng Wang, Quanyin Tan, Joseph F. Chiang, Jinhui Li

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Characteristics and Exploitation of Rare Earth,Rare Metal and Rare-Scattered Element Minerals in China

Wang Denghong, Sun Yan, Dai Hongzhang, Guo Weiming, Zhao Zhi, Zhao Ting,Li Jiankang, Wang Chenghui, Huang Fan, Yu Yang, Li Dexian

Journal Article

Migration of ammonium nitrogen in ion-absorbed rare earth soils during and post mining: a column study

Journal Article

Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Journal Article

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Journal Article

Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Journal Article

Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Journal Article